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CANCIDAS PACKAGE INSERT PDF

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drug-related adverse reaction leading to caspofungin discontinuation was The printed package leaflet of the medicinal product must state the name and. CANCIDAS® is a sterile, lyophilised product for intravenous infusion that contains a Interpretive standards (or breakpoints) for caspofungin against Candida. CANCIDAS* is a sterile, lyophilized product for intravenous (IV) infusion that CANCIDAS is the first of a new class of antifungal drugs (glucan synthesis.

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IV echinocandin antifungal Used for aspergillosis, candidemia, esophageal candidiasis, and empiric treatment in febrile neutropenia Fever and infusion-related reactions common. In lung transplant recipients with tracheobronchial aspergillosis TBA associated with anastomotic endobronchial ischemia or inzert reperfusion injury, inhaled amphotericin B deoxycholate is suggested in addition to systemic therapy; treat for at least 3 months or until TBA is resolved, whichever is longer.

Caspofungin is classified in FDA pregnancy risk category C. Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. National Institutes of Health, U. Studies to evaluate the effects of exposure on a breast-fed infant have not been conducted; however, based on caspofungin’s poor oral absorption, the risks appear to be low. Reconstituted caspofungin in the vial may be stored at 25 degrees C or less 77 degrees F or less for 1 hour prior to dilution.

It is not known how caspofungin drug clearance is induced. Do not mix or co-infuse caspofungin with other medications or infuse with dextrose-containing solutions. Dosage and administration 2. Drugs that may lead to reductions in caspofungin concentrations include dexamethasone. Because of the risk of relapse of oropharyngeal candidiasis in patients with HIV infections, suppressive oral therapy could be considered [see see package insert Clinical Studies A mg loading dose has not been studied with this indication.

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Activity in vitro Caspofungin has been shown to be active both in vitro and in clinical infections against most strains of the following microorganisms:.

Five of the 14 cases and one case of elevated bilirubin were considered possibly related to concomitant therapy; no clinical evidence of hepatotoxicity or serious hepatic events occurred.

Beta 1,3 -D-glucan is not present in mammalian cells and therefore is an attractive target for antifungal activity. For the treatment of respiratory infections i. Clinically significant elevations in caspofungin plasma concentrations have been noted in patients with moderate hepatic impairment i.

Do not administer as an IV bolus injection. Theoretically, rifabutin and rifapentine could also decrease caspofungin blood concentrations. Restrict treatment to pneumonia associated with disseminated infection.

Cancidas (caspofungin acetate) dose, indications, adverse effects, interactions from

Limited safety data suggest that an increase in dose to 70 mg daily is well tolerated. Mechanism of Action Caspofungin acetate, an echinocandin, is an antifungal agent. For empirical therapy for presumed fungal infection in patients with febrile neutropenia.

Monitor potentially exposed infants for gastrointestinal adverse events and signs of histamine release. Morphologically, fungi hyphae and yeast shapes are altered. Duration of treatment should be individualized to the indication, as described for each indication in adults [see Dosage and Administration 2.

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Ophthalmological examination is recommended for all patients.

Caspofungin Acetate for Injection Now Available from Fresenius Kabi

According to the manufacturer, drugs that may lead to reductions in caspofungin concentrations include carbamazepine. Treat for several weeks, followed by oral fluconazole for patients who are unlikely to have a fluconazole-resistant isolate. Treat for 2 weeks after documented clearance from the bloodstream and resolution of signs and symptoms.

Aspergillus fumigatus Aspergillus flavus Aspergillus terreus Candida albicans Candida glabrata Candida guilliermondii Candida krusei Candida parapsilosis Candida tropicalis. Aspergillosis clinical practice guidelines suggest caspofungin as a first line empiric therapy. Caspofungin Acetate for Injection is an echinocandin antifungal indicated in adults and pediatric patients 3 months of age and older for: Caspofungin has not been studied for safety and efficacy in infants less than 3 months of age, including neonates.

Fresenius Kabi is a global health care company that specializes in medicines and technologies for infusion, transfusion and clinical nutrition.

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Esophageal Candidiasis The dose should be 50 mg daily. Do not store for later use.

Caspofungin is contraindicated for use in patients with hypersensitivity to the drug or any of its components.